Annie Kathuria
Annie Kathuria is a neuroscientist currently working at Harvard Medical School, Psychiatry Department, as an Instructor of Investigation.[1][2] She is affiliated with Chemical Biology and Therapeutics Science at the Broad Institute of MIT and Harvard, Massachusetts General Hospital and Harvard Stem Cell Institute.[1] She usually does her research in Tissue Engineering, Neurosciences, Genetics and Development Biology.[3]
Education
Annie Kathuria did her Double Major in Neuroscience and Genetics Cell Biology and Development at University of Minnesota. Then she completed her Master of Science from King’s College London. And then from the same institute she did her PhD.[4][5] During her time in her PhD she trained under Drs. Jack Price, Fiona Watt, and Simon Baron Cohen.
Research work
Annie Kathuria has over 680 citations[6] from publications among them distinctive work is following:
- “Stem Cell “MINI-BRAINS” for studying the Biology of Bipolar Disorder” published on September 9, 2020, on Genome Medicine. Kathuria was a postdoctoral research fellow in Center for Genomic Medicine, Massachusetts General Hospital. In her study, she initiated pluripotent stem cells (iPSCs) were produced from skin cells from patients with bipolar disorder (BPD) and solid control subjects, which were at that point utilized to form cerebral organoids, three-dimensional neuronal culture frameworks that summarize the advancement of the human forebrain.[7]
- “Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia” by Annie Kathuria.[3][8]
- Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development, published in 2018.[9] Through this study, Dr. Kathuria established a robust method of generating stem cells from hair cells and found a viable therapeutic target for treating autism caused neurological deficits using gene therapy.
- “Distinct effects of interleukin-6 and interferon-? on differentiating human cortical neurons” published in April 2022.[3] “Synaptic Deficit in iPSC-derived cortical Interneurons in Schizophrenia is mediated by NLGN2 and rescued by N-acetylcyteine” by Annie Kathuria, published on March 18,2020.[3][10][11] In this publication, she has found a potential drug for the treatment for the oxidative stress frequently reported in schizophrenia. Such work serves as the basis for larger clinical trials and represents a viable therapeutic agent against this devasting disorder.
Critical reception
Annie Kathuria has a distinctive list of her awards. This series started in the year 2012 when she got King's College London International Scholar Award (2012-2015). In 2016, she was honored with AbbVie Innovation Challenge Award. Furthermore, she got King's College London Health and Innovation Award (2016-2017). In 2018, Kathuria got Molecular Psychiatry Association Investigator Award and Harvard Brain Science Initiative Young Scientist Award. In 2019, Society for Neuroscience/Japanese Neuroscience Society (JNS) Travel Award and then on January 17, 2020 Annie Kathuria received NARSAD Young Investigator Award from Brain and Behavior Research Foundation.[12] In 2021 she was honored with JEDI award from the Life Science Editors Foundation[13] and Anne Klibanski Scholar's Award (2020-2021). She has won another international award which is recently announced June 12th Samuel Gershon Award for Junior Investigator. She also has a book deal, signed with nova publications on “Techniques of tissue engineering”.[14]
References
- ↑ 1.0 1.1 "Man-Made Brain" (in en). https://www.psychologytoday.com/blog/man-made-brain.
- ↑ "Clinical Neurology and Neuroscience :: Science Publishing Group". https://www.sciencepublishinggroup.com/journal/editorialboard?journalid=271.
- ↑ 3.0 3.1 3.2 3.3 "researchgate.net/profile/Annie-Kathuria-2". https://www.researchgate.net/profile/Annie-Kathuria-2.
- ↑ "linkedin.com/in/anniekathuria103". https://www.linkedin.com/in/anniekathuria103.
- ↑ "researchgate.net/profile/Annie-Kathuria-2". https://www.researchgate.net/profile/Annie-Kathuria-2.
- ↑ "Annie Kathuria". https://scholar.google.com/citations?user=5xHrw3kAAAAJ&hl=en.
- ↑ ""Mini-Brains" Created Stem Cells Studying Biology of Bipolar Disorder" (in en). https://advances.massgeneral.org/neuro/journal.aspx?id=1670.
- ↑ Kathuria, Annie; Lopez-Lengowski, Kara; Jagtap, Smita S.; McPhie, Donna; Perlis, Roy H.; Cohen, Bruce M.; Karmacharya, Rakesh (2020-07-01). "Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell–Derived Cerebral Organoids in Schizophrenia". JAMA Psychiatry 77 (7): 745–754. doi:10.1001/jamapsychiatry.2020.0196. ISSN 2168-622X. https://doi.org/10.1001/jamapsychiatry.2020.0196.
- ↑ Kathuria, A.; Nowosiad, P.; Jagasia, R.; Aigner, S.; Taylor, R. D.; Andreae, L. C.; Gatford, N. J. F.; Lucchesi, W. et al.. "Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development" (in en). Molecular Psychiatry 23 (3): 735–746. doi:10.1038/mp.2017.185. ISSN 1476-5578. https://www.nature.com/articles/mp2017185.
- ↑ Kathuria, Annie; Lopez-Lengowski, Kara; Watmuff, Bradley; McPhie, Donna; Cohen, Bruce M.; Karmacharya, Rakesh (2019-11-28). "Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine" (in en). Translational Psychiatry 9 (1): 1–13. doi:10.1038/s41398-019-0660-x. ISSN 2158-3188. https://www.nature.com/articles/s41398-019-0660-x.
- ↑ Karmacharya, Rakesh; Watmuff, Bradley; Kathuria, Annie; Liu, Bangyan (2018-04-01). "S193. EX VIVO SIGNATURE OF PSYCHOSIS AND TREATMENT RESPONSE IN PATIENT-DERIVED NEURONS". Schizophrenia Bulletin 44 (suppl_1): S400–S400. doi:10.1093/schbul/sby018.980. ISSN 0586-7614. https://doi.org/10.1093/schbul/sby018.980.
- ↑ PhD, Ruta Nonacs, MD (2020-01-17). "Annie Kathuria, PhD Receives NARSAD Young Investigator Award" (in en-US). https://mghpsychnews.org/dr-annie-kathuria-receives-narsad-young-investigator-award/.
- ↑ "Success Stories – Life Science Editors Foundation" (in en-US). https://lifescienceeditors.org/success-stories/.
- ↑ "Annie Kathuria | Harvard Catalyst Profiles | Harvard Catalyst". https://connects.catalyst.harvard.edu/Profiles/display/Person/164740.
